Human HOX gene disorders
نویسندگان
چکیده
منابع مشابه
The human HOX gene family.
We report the identification of 10 new human homeobox sequences. Altogether, we have isolated and sequenced 30 human homeoboxes clustered in 4 chromosomal regions called HOX loci. HOX1 includes 8 homeoboxes in 90 kb of DNA on chromosome 7. HOX2 includes 9 homeoboxes in 180 kb on chromosome 17. HOX3 contains at least 7 homeoboxes in 160 kb on chromosome 12. Finally, HOX4 includes 6 homeoboxes in...
متن کاملNucleosome positioning in human HOX gene clusters.
The distribution of nucleosomes along the genome is a significant aspect of chromatin structure and is thought to influence gene regulation through modulation of DNA accessibility. However, properties of nucleosome organization remain poorly understood, particularly in mammalian genomes. Toward this goal we used tiled microarrays to identify stable nucleosome positions along the HOX gene cluste...
متن کاملSnapShot: Hox Gene Regulation
d12 d13 d10 d11 d11 d13 d11 d10 d9 d8 d4 d3 d1 d12 c13 c11 c10 c9 c6 c5 c4 c12 c8 b13 b9 b7 b6 b5 b4 b3 b2 b1 b8 a13 a11 a10 a9 a7 a6 a5 a4 a3 a2 a1 HoxA HoxB HoxC d13 d11 d10 d9 d8 d4 d3 d1 d12
متن کاملAnalysis of HOX gene expression patterns in human breast cancer.
HOX genes are highly conserved transcription factors that determine the identity of cells and tissues along the anterior-posterior body axis in developing embryos. Aberrations in HOX gene expression have been shown in various tumors. However, the correlation of HOX gene expression patterns with tumorigenesis and cancer progression has not been fully characterized. Here, to analyze putative cand...
متن کاملHox gene variation and evolution.
8 annually degasses about 1 gigatonne (10 tonnes) of CO2 (ref. 3), equivalent to 20 per cent of current anthropogenic output. The regression lines and intercepts of dissolved inorganic carbon, silicate and nitrate concentrations, measured in the upper 200 m of the EUZ, indicate that silicate availability regulates both carbon and nitrate uptake and fate. The slope of the highly significant regr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Genetics and Metabolism
سال: 2014
ISSN: 1096-7192
DOI: 10.1016/j.ymgme.2013.10.012